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The potential of dual stage turbocharging and Miller Cycle for a six cylinders in line, 13 litres displacement, HD diesel engine was analysed in this work, by means of a 1-D engine simulation fluid dynamic code, coupled with a multi-zone combustion model for NOx and PM prediction. After a detailed validation process, based on an extensive experimental data set, the engine model was then used to predict the effects on engine performance and emission characteristics of different combinations of dual stage turbochargers, engine compression ratio values and intake valve lift profiles. The potential for an appreciable increase in the engine power, with a slight decrease in the specific fuel consumption and a remarkable decrease of NOx specific emissions was demonstrated.