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A biologically based Air Revitalisation System is compared with the proposed conventional options for a 3 man US Space Station Initial Operating Configuration, (IOC). Whereas previous work has been based on laboratory experiments, this paper attempts to define the practical engineering requirements of such a system. Although the proposed system does not offer advantages in terms of overall equivalent weight, it does form the basis for a totally safe system and provides the potential to combine Air, Water and Waste Management Systems. These details have been used to identify a potential strategy for the development of an Air Revitalisation System, which based on the combined use of conventionally derived equipment and an Algal Bioreactor, could contribute to the long term development of a Controlled Ecological Life Support System, (CELSS).