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In highly automated vehicles (HAVs), new seat configurations may be desirable to allow occupants to perform new activities. One of the current HAV concepts is the swiveled seat layout, which might facilitate communication between occupants. The main objective of this study was to investigate the effects of seat swiveling angles on occupant kinematics and injury risk predicted by a Human Body Model (HBM) during a frontal impact. A detailed 50th percentile male HBM (GHBMC M50-O) was subjected to two frontal crash pulses in a sled setup. The model was positioned on a semi-rigid seat and restrained using a pre-inflated airbag and a three-point seatbelt. Simulations included four seat swiveling angles (0, -10, -20, and -30 degrees), three occupant positions (Sedan driver, large VAN driver or Laptop user), two airbag initial locations (nominal or matching the head Y location), and the inclusion of lateral supports on the seat pan.