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The use of particulate filters (DPF) has become in recent years the state of the art technology for the reduction of soot aerosol emissions for light, medium and heavy duty Diesel vehicles. However, the effect of the system location on engine performance is a key aspect that should be studied. In the present work a numerical study has been carried out with the objective to analyze the effect on the engine performance of an innovative DPF placement upstream of the turbine. This study has been performed by means of the gas dynamic simulation of a two-stage turbocharged heavy duty Diesel engine, which has been previously modeled from experimental data obtained under steady state conditions. The original DPF has been divided into two monoliths for the case of the pre-turbo DPF configuration. Three cylinders discharge in each of these monoliths and after the filtration the flow is driven towards the high-pressure turbine and the EGR system.