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This study applies a detailed finite element model of the human body to simulate occupant knee impacts experienced in vehicular frontal crashes. The human body model includes detailed anatomical features of the head, neck, chest, thoracic and lumbar spine, abdomen, and lower and upper extremities. The material properties used in the model for each anatomic part of the human body were obtained from test data reported in the literature. The total human body model used in the current study has been previously validated in frontal and side impacts. Several cadaver knee impact tests representing occupants in a frontal impact condition were simulated using the previously validated human body model. Model impact responses in terms of force-time and acceleration-time histories were compared with test results. In addition, stress distributions of the patella, femur, and pelvis were reported for the simulated test conditions.