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Carbon neutrality has become a significant target. One essential parameter regarding energy consumption and emissions is the mass of vehicles. Lightweight design improves the result of vehicle life cycle assessment (LCA), increases efficiency, and can be a step towards sustainability and CO2 neutrality. Weight reduction through structural optimization is a challenging task. Typical design development procedures have to be overcome. Instead of just a facelift or the creation of a derivative of the predecessor design, completely alternative design creation methods have to be applied. Automated structural optimization is one tool for exploring completely new design approaches. Different methods are available and weight reduction is the focus of topology optimization. This paper describes a fatigue life homogenization method that enables the weight reduction of vehicle parts. The applied CAE process combines fatigue life prediction and topology optimization.