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High octane fuel (e.g., E85) effectively suppresses knock, but the octane ratings of such fuels are much above what is required under normal driving conditions. It is important, therefore, to understand the octane requirement of the engine itself over its full range of operation and apply that knowledge to practical driving cycles to understand fuel octane utilization, especially of a turbocharged engine. By carefully defining knock limits, the octane requirement of a 2-liter turbocharged spark ignition engine was experimentally quantified over a wide range of loads and speeds using PRF blends and gasoline-ethanol blends. Utilizing this knowledge and engine-in-vehicle simulations, the octane requirements of various driving cycles were calculated for a passenger car and a medium duty truck model.