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As an important means of engine development and optimization, modelbuilding plays an increasingly important role in reducing carbon dioxide emissions of the internal combustion engines (ICEs). However, due to the non-linearity and high dimension of the engine system, a large amount of data is required to obtain high model accuracy. Therefore, a modelling approach combining the experimental data and prior knowledge was proposed in this study. With this method, an artificial neural network (ANN) model simulating the engine brake specific fuel consumption (BSFC) was established. With mean square error (MSE) and Kullback-Leibler divergence (KLD) serving as the fitness functions, the 86 experimental samples and constructed physical models were used to optimize the ANN weights through genetic algorithms.