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Climate change demands urgent actions towards CO2 emission reduction. Through their effect on friction losses, new engine lubricants play a key role in reducing fuel consumption and, consequently, CO2 emissions. Besides oil viscosity optimization, friction contributions are primarily dependent on friction reducer (FR) chemistry, although secondary impacts exist for detergent, dispersant, and antiwear additives. The authors have been working for several years in the development of innovative friction reducer additives as well as in the definition of testing methods for evaluating the performances of a large number of molecules and selecting the most promising ones for engine or vehicle tests.