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Hydrogen Internal Combustion Engines (H2-ICEs) are being investigated due to their minimal criteria pollutant and zero CO2 tailpipe emissions. However, oil filters and non-hot joint gaskets have rubber material that can be damaged and deteriorate due to direct or indirect exposure to the high temperature and high-pressure hydrogen in a H2-ICE. Thus, the effects on the properties of a rubber exposed to a hydrogen environment need to be reviewed. In this review paper, the transportation, chemical and mechanical properties of a rubber exposed directly or indirectly to high temperature and high-pressure hydrogen in a H2-ICE have been reviewed. The compatibility of rubber materials used in H2-ICE has been explored. The effects of high-pressure hydrogen on the transportation, chemical and mechanical properties of NBR and HNBR have been reviewed.