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Design for Six Sigma (DFSS) is a product improvement process based on statistical problem solving capabilities which is typically followed IDDOV approach - Identify, Define, Develop, Optimize, and Verify the design. Flexible inspection system (FIS) is defined as one where the inspection routines are not fixed but are determined just prior to performing the inspection [1]. In FIS the inspection stations have the capacity of performing different inspection routines according to a global inspection strategy. In this paper, the IDDOV steps, as well as some DFSS variation analysis techniques, are applied with the FIS to provide an analytical framework for an optimized strategy of real time inspection allocations.