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Speech enhancement can extract clean speech from noise interference, enhancing its perceptual quality and intelligibility. This technology has significant applications in in-car intelligent voice interaction. However, the complex noise environment inside the vehicle, especially the human voice interference is very prominent, which brings great challenges to the vehicle speech interaction system. In this paper, we propose a speech enhancement method based on target speech features, which can better extract clean speech and improve the perceptual quality and intelligibility of enhanced speech in the environment of human noise interference. To this end, we propose a design method for the middle layer of the U-Net architecture based on Long Short-Term Memory (LSTM), which can automatically extract the target speech features that are highly distinguishable from the noise signal and human voice interference features in noisy speech, and realize the targeted extraction of clean speech.