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Rapid advances in cloud-based computing, robotics and smart sensors, multi-modal modeling and simulation, and advanced production are transforming modern manufacturing. The shift toward smaller runs on custom-designed products favors agile and adaptable workplaces that can compete in the global economy. This paper and presentation will describe the advances in Digital Manufacturing that provides the backbone to tighten integration and interoperability of design methods interlinked with advanced manufacturing technologies and agile business practices. The digital tapestry that seamlessly connects computer design tools, modeling and simulation, intelligent machines and sensors, additive manufacturing, manufacturing methods, and post-delivery services to shorten the time and cost between idea generation and first successful product-in-hand will be illustrated.