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The main purpose of this research is to investigate the optimal design of pipeline diameter in an air brake system in order to reduce the response time for driving safety using DOE (Design of Experiment) method. To achieve this purpose, this paper presents the development and validation of a computer-aided analytical dynamic model of a pneumatic brake system in commercial vehicles. The brake system includes the subsystems for brake pedal, treadle valve, quick release valve, load sensing proportional valve and brake chamber, and the simulation models for individual components of the brake system are established within the multi-domain physical modeling software- AMESim based on the logic structure. An experimental test bench was set up by connecting each component with the nylon pipelines based on the actual layout of the 4×2 commercial vehicle air brake system.