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To fullfill continually decreasing future emission standards, combined exhaust aftertreatment systems consisting of different catalyst technologies and particulate filter are necessary. Over the lifetime of such systems, catalytic performance of all individual components decreases due to thermal aging and poisoning effects. This has to be taken into account during system design as well as during the development of the operating and control strategies, to ensure long term system performance. Especially in commercial vehicle applications, this is an important issue because of long vehicle lifetimes in terms of mileage. In combined aftertreatment systems, the thermal histories of the catalytic components are linked and influence each other. Especially in systems containing a diesel particulate filter, thermal aging of all components is mainly dominated by the active DPF regeneration strategy for the filter.