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Human-driven vehicles are going to be replaced by highly automated vehicles as one of the future mobility trends. Even though highly automated vehicles’ active safety systems can protect against vehicle-to-vehicle accidents, the traffic mix between human-driven vehicles and highly automated vehicles is still a potential source of vehicle collisions. Additionally, occupants in highly automated vehicles will be passengers not necessarily dealing with driving anymore, so there will be a considerable number of non-standard seating configurations. Those configurations are not able to be assessed for safety by hardware testing due to their number, variability and complexity. The objective of the paper is the development of a fast virtual approach to identify the passengers’ injury risk in non-standard seating configurations under multi-directional impact scenarios and severity.