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Air-conditioning and Refrigeration systems are widely used in many industries for cooling and preservation, and the evaporator is a crucial component responsible for heat absorption. The choice of refrigerant has a significant impact on the evaporator's performance, affecting the overall efficiency of the system. This paper investigates the effect of three common refrigerants, R134a, R407c, and R1234yf, on evaporator performance. A comparative analysis was performed using the conventional air-conditioning system consisting of a compressor, condenser, expansion valve, and evaporator. The evaporator performance was evaluated based on the cooling capacity, Refrigerant Side Pressure Drop (RSPD) and Superheat (SH). The results show that evaporator has highest cooling capacity with R134a, followed by R407C and R1234yf. In comparison to R134a, R1234yf had the lowest refrigerating effect followed by R407C.