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This article describes a NOx sensor based urea dosing control strategy for heavy-duty diesel aftertreatment systems using Selective Catalytic Reduction. The dosing control strategy comprises of a fast-response, model-based ammonia storage control system in combination with a long-timescale tailpipe-feedback module that adjusts the dosing quantity according to current aftertreatment conditions. This results in a control system that is robust to system disturbances such as biased NOx sensors and variations in AdBlue concentrations. The cross-sensitivity of the tailpipe NOx sensor to ammonia is handled by a novel, smart signal filter that can reliably identify the contributions of NOx and NH3 in the tailpipe sensor signal, without requiring an artificial perturbation of the dosing signal.