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Nowadays, the automobile industry is booming and the number of vehicles is proliferating while the road traffic environment is also deteriorating. Therefore, attention should be paid to the protection of vulnerable road users in traffic accidents, such as pedestrians. In order to reduce the pedestrians’ head injury in collision accidents, in this study, the vehicle engine hood which responds significantly to head injuries was taken as the design object, so as to put forward a new optimization design process. The parameters of the hood’s main components, manufacturing materials and structural scheme were considered to carry out simultaneous optimization from various aspects such as pedestrian protection and hood stiffness.