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Future human space exploration missions present significant challenges for life support system (LSS) development. These life support systems will require incorporation of regenerative technologies to reduce or eliminate expendables and be low risk, demonstrating high reliability and long-term performance capability. A regenerative LSS for Space Station is a key step toward meeting these future space exploration requirements. In the development of the Space Station regenerative LSS, the challenges have been both technical and budgetary. Currently, the International Space Station Alpha (ISSA) program will consist of three Phases. Phase I will be MIR/Shuttle Orbiter flights with United States (US) crews attending to the various US flight experiments on-board the MIR. Phase II will consist mostly of Russian launched modules and the United States (US) Laboratory module. Phase III will launch the US Habitat module to implement US regenerative LSS.