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MARES (Muscular Atrophy Research and Exercise System) is a system for neuromuscular research. This system is an ergometer to be flown and installed in the International Space Station in the year 2004. The system consists of a control electronics that controls a motor, to which a subject is connected by means of a restraining system named HRS (Human Restraint System). This ergometer can be used for 11 movements (wrist flexion/extension, wrist pronation/supination, and wrist radial/ulnar deviation; trunk flexion/extension; arm pull/press, leg pull/press; elbow flexion/extension; Shoulder flexion/extension; hip flexion/extension; knee flexion/extension; and ankle dorsal/plantar flexion). The HRS must meet the following anthropometric range: from 5 percentile Japanese female to 95 percentile American male. The complete MARES system follow the verification of the specifications set at the start of the project.