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Maintaining a healthy atmosphere in closed life support systems is essential for the crew well being and the success of manned space missions. During the SBIR Phase I effort, Lynntech, Inc., developed a bench scale trace contaminant control (TCC) system utilizing a photocatalytic filter. Testing successfully demonstrated the technology feasibility for eliminating airborne chemicals and microorganisms. During the SBIR Phase II project, a scaled-up, fully operational breadboard system is being developed and tested. Testing gases include chemicals significantly present in the International Space Station cabin air and that are drivers in the design of trace contaminant control systems. The use of Lynntech’s air cleaner allows for a system that is cost-effective and functional with a superior removal of gas pollutants and bio-aerosols from contaminated air streams beyond the capabilities of traditional photocatalysis. It also overcomes limitations of current TCC systems.