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The National Aeronautics and Space Administration (NASA) intends to continue the human exploration of outer space. Long duration missions will require the development of reliable regenerative life support processes. The intent of this paper is to define the Kennedy Space Center Controlled Ecological Life Support System (CELSS) research plan for the development and testing of three candidate biological processors for a hybrid biological and physical-chemical waste recycling system. The system would be capable of reclaiming from inedible plant biomass, human metabolic waste, and gray water those components needed for plant growth (carbon dioxide, water, and inorganic salts), while eliminating noxious compounds and maximizing system closure. We will colaborate with AMES Research Center (ARC), Johnson Space Center (JSC), and academia, to design a functional biological-based waste processing system that could be integrated with the planned Human Rated Test Facility (HRTF) at JSC.