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A new system has been designed to simulate orbital-extravehicular (EVA) work to provide for real-time measurement of physiological parameters. Such a system described here incorporates an experimental protocol, exercising subject, controlled-atmosphere chamber, EVA-work simulation exercise device, medical instrumentation and a data acquisition system. Applications of the neutral-buoyancy method and other laboratory-simulation methods are described. This information is presented to facilitate the understanding of this exercise device as a possible additional orbital-EVA work-simulation tool. Important engineering issues associated with the design of the proposed system are discussed.