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In the period between mid-1997 and 2000, a team at NASA's Johnson Space Center broke with historical paradigms by developing the first endoskeletal space module. The value of this design was cost-effectiveness and efficiency, and also the possibilities its technical success has created for new forms to support human-rated vehicles and modules for exploration missions. The “TransHab Paradigm” is a complex, semi-inflatable vehicle whose two basic configurations - launch and deployed - are each optimized for their respective environments while retaining fundamental system integration for autonomy and efficient deployment. An early lesson of this new paradigm is its adaptability to a wide array of formal solutions for different sets of requirements.