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A previously developed two-dimensional model of a vehicle in a lateral roll (Rose, et al. 2008) was used in this study to analytically evaluate the effect of vehicle roll angle and roll velocity on roof-impact ΔV and consequent occupant injury mechanism and risk. Both occupants adjacent to (near-side) and remote from (far-side) the rollover’s leading side were evaluated. Injury evaluation was limited to head and neck/spinal injuries. The vehicle’s roll angle at the time of roof-impact dramatically affected the local ΔV at the point of head-to-roof contact. Both roof-rail impacts may be injurious to far-side occupants, while near-side occupants are more likely to sustain head or neck injuries in roof impacts with the adjacent roof rail. Far-side occupants have a greater risk of compressive neck injury during impacts with the remote roof rail, while adjacent roof rail impacts subject occupants to primarily lateral head impacts with a higher head injury risk.