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The objectives of this study were to provide insights on how injury risk is influenced by occupant demographics such as sex, age, and size; and to quantify differences within the context of commonly-occurring real-world crashes. The analyses were confined to either single-event collisions or collisions that were judged to be well-defined based on the absence of any significant secondary impacts. These analyses, including both logistic regression and descriptive statistics, were conducted using the Crash Investigation Sampling System for calendar years 2017 to 2021. In the case of occupant sex, the findings agree with those of many recent investigations that have attempted to quantify the circumstances in which females show elevated rates of injury relative to their male counterparts given the same level bodily insult. This study, like others, provides evidence of certain female-specific injuries.