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The objective of this investigation was to understand relationships among loading characteristics as they affect the kinematics and injury of a pedestrian’s lower extremity. Real-life pedestrian and motor vehicle collision scenarios were modeled by impacting 604 human cadaver intact legs and long bones with a cart/guide rail impacting system designed to simulate the front end of an automobile. A parametric study was conducted that varied the boundary conditions on the foot as well as test parameters such as loading direction, impact velocity, and impactor geometry. The series of tests can be categorized as follows: (1) Fracture Characterization, (2) Threshold Velocity, (3) Friction versus Inertial Constraint, (4) Anterior and Lateral Thigh Impacts, and (5) Embalmed vs. Unembalmed. Documented data for various specimens include, but are not limited to, specimen anthropometrics, fracture patterns, failure force levels, and calculated bending moments.