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This paper deals with a Systems Approach for the Design of an Integrated Regenerative Life Support system (he IRLSS) based on physico-chemical methods of transforming of the crew metabolic-waste products to the controlled human environment components. To solve the initial problem of the technology's synthesis the following principal questions are going to be considered: (a) the formation of alternatives discrete set; (b) the elaboration of the integral and hypothesis structure fr IRLSS and its formal description; (c) the creation of the methodology and information support and the associated software. The IRLSS database and the application of the given software for the solution of the design's individual problems will also be discussed.