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A Human Factors Engineering (HFE) analysis has been involved in the design process of the Mini Pressurized Logistics Module (MPLM) for the International Space Station (ISS) since the beginning, as an integrated part of the design support activities. The support of HFE in the configuration process has been directed towards the optimization of the MPLM design through the analysis and evaluation of all the interfaces occurring in the module - nominal and non-nominal - between the crew, the system and the subsystem equipment. In order to identify and analyze all the crew interfaces occurring inside the module, a systematic approach, involving different disciplines, is necessary. The integration of three different tools such as computer simulation, task analysis and mock-up test activities has been employed as an organic unit, in order to establish a comprehensive collection of useful data.

In the overall planning of a manned mission to Mars, all the issues related to human involvement are critical. To a certain extent, they dictate the most severe constraints on the mission scenario and spacecraft architecture. Despite this unanimously recognized importance, limited efforts have been devoted up to now to dedicated research activities on human-related aspects, partially neglected w.r.t. more technical areas like orbital dynamics, propulsion, power generation, etc. This paper summarizes the major results of a survey on the human factors of long duration missions performed by Alenia Spazio in the frame of an ESA study, MARSEMSI, whose aim was to identify possible scenarios and related infrastructure requirements for a manned mission to Mars.