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There is a trend in the automotive industry to reduce the number of physical prototypes and to rely more on Computer Aided Engineering (CAE) for sizing and final design of vehicle structures. The traditional deterministic approach does not necessarily clarify the degree of variability and conservatism. With small variability in influence parameters and a design factor for final design, the approach may be over conservative resulting in weight and cost penalty. On the other hand, with large variability and the same design factor, the deterministic approach may not satisfy durability requirements. It is important to identify the variability of all factors including road loads and sensitivities of the control parameters, and to minimize their effects on durability so that fatigue life distribution meets the durability requirements.