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In applying ceramic honeycomb wall flow type filters to the after-treatment systems of diesel particulate from engines, the melting and thermal shock failures of ceramic diesel particulate filters (DPF) have been considered as one of the most significant issues during regeneration. This paper gives the results of experiments on the effects of cell structure i.e., wall thickness and cell density, on the melting and thermal shock regeneration failure of DPF and proposes an optimized cell structure for DPF in terms of the regeneration failure and the pressure drop which is also considered to be one of the especially important issues in fuel economy for heavy duty vehicle application.