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Stress, fatigue, and workload affect worker performance. NSF reported that 61% of respondents state losing concentration at work while 19% occasionally or frequently made errors as a result of being fatigued. Shift work, altered work schedules, long hours of continuous wakefulness, and sleep loss can create sleep and circadian disruptions that degrade waking functions causing stress and fatigue [2]. Review of the literature has proven void of information that links the combined effects of fatigue, stress, and workload to human performance. This paper will address which occupational factors within stress, fatigue, and workload were identified as occupational contributors to performance changes. The results of this research will be applied to underlying models and algorithms that will help predict performance changes in control room operators.