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Bus transport is an important element in a sustainable transport strategy. The objective of this study is to understand crashes and injuries involving buses, suggest potential passive-safety interventions, estimate their effectiveness, and compare their effectiveness between Germany and India. Descriptive analysis of crash data from the German In-depth Accident Study (GIDAS) and the Road Accident Sampling System India (RASSI) database was performed in two parts: First, bus passengers and their injuries were analyzed and second, pedestrian injuries in bus-to-pedestrian crashes were analyzed. Lastly, interventions were suggested, and their effectiveness was estimated. Analysis of bus passengers showed that most moderate-to-critical injuries in the GIDAS data were to the head caused by interior bus components. In the RASSI data, head injuries were also frequent, often due to bus interior contact, but also due to ejection and impact to the ground or bus exterior.