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Traditional manufacturing processes such as injection or compression molding are often enclosed and pressurized systems that produce homogenous products. In contrast, 3D printing is exposed to the environment at ambient (or reduced) temperature and atmospheric pressure. Furthermore, the printing process itself is mostly “layered manufacturing”, i.e., it forms a three-dimensional part by laying down successive layers of materials. Those characteristics inevitably lead to an inconsistent microstructure of 3D printed products and thus cause anisotropic mechanical properties. In this paper, the anisotropic behaviors of 3D printed parts were investigated by using both laboratory coupon specimens (bending specimens) and complex engineering structures (A-pillar). Results show that the orientation of the infills of 3D printed parts can significantly influence their mechanical properties.