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After several decades of human spaceflight, the community of space-faring nations has accumulated a diverse and sometimes harrowing history of toxicological events that have plagued human space endeavors almost from the very beginning. Some lessons have been learned in ground-based test beds and others were discovered the hard way - when human lives were at stake in space. From such lessons one can build a risk-management framework for toxicological events to minimize the probability of a harmful exposure, while recognizing that we cannot predict all possible events. Space toxicologists have learned that relatively harmless compounds can be converted by air revitalization systems into compounds that cause serious harm to the crew.

As mission length and the number and complexity of payload experiments increase, so does the probability of thermodegradation contingencies (e.g. fire, chemical release and/or smoke from overheated components or burning materials), which could affect mission success. When a thermodegradation event occurs on board a spacecraft, potentially hazardous levels of toxic gases could be released into the internal atmosphere. Experiences on board the Space Shuttle have clearly demonstrated the possibility of small thermodegradation events occurring during even relatively short missions. This paper will describe the Combustion Products Analyzer (CPA), which is being developed under the direction of the Toxicology Laboratory at Johnson Space Center to provide necessary data on air quality in the Shuttle following a thermodegradation incident.

NASA has unique requirements for the development and application of air quality standards for human space flight. Such standards must take into account the continuous nature of exposures, the possibility of increased susceptibility of crewmembers to the adverse effects of air pollutants because of the stresses of space flight, and the recognition that rescue options may be severely limited in remote habitats. NASA has worked with the National Research Council Committee on Toxicology (NRCCOT) since the early 1990s to set and document appropriate standards. The process has evolved through 2 rounds. The first was to set standards for the space station era, and the second was to set standards for longer stays in space and update the original space station standards. The update was to be driven by new toxicological data and by new methods of risk assessment for predicting safe levels from available data. The last phase of this effort has been completed.

For long duration space flights, wastewater from humidity condensate, urine, and used hygiene water will be recycled to provide an adequate supply of potable quality water for the crew. Due to the diverse nature and multiple sources of contaminants entering the recycling system, it is a challenge to maintain the quality of product water such that no adverse health effects occur. NASA Johnson Space Center in cooperation with the Committee on Toxicology of the National Research Council (NRCCOT) has developed a science-based approach, taking into consideration space flight induced factors, to derive Spacecraft Water Exposure Guidelines (SWEG) for 1, 10, 100, 1000 days of consumption. This paper will discuss the ongoing process of setting SWEGs, how candidate chemicals were chosen for risk assessment, and how various toxicological data are collected and interpreted. Our goal is to help environmental engineers understand how the SWEGs they use for hardware design are developed.