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A combination of finite element modeling and sled test reconstruction of real-world infant head injury scenarios has been used to investigate infant head impact response and tolerance to skull fracture. Studying the role of cranial sutures on infant skull response was of particular interest. The specific injury scenarios selected for reconstruction involved infants in rear-facing child restraint systems (CRS) who sustained skull fractures and brain injuries from deploying passenger-side frontal airbags. Approximations of the loading conditions for three injury cases, as well as estimates of loading conditions not expected to result in head injury, were produced in the laboratory. A finite element model (FEM) of a six-month-old infant head was developed using available material properties and humanlike geometry. The infant head FEM was used to simulate different injury and no-injury loading conditions based on CRS response data from the reconstruction tests.