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Bioreactor technology is currently being developed by a team of NASA and major aerospace companies to provide capabilities for water reclamation within a Regenerative Life Support System (RLSS). An integrated approach is being used for this development process consisting of fundamental laboratory studies, full-scale experimental studies and mathematical modeling. The laboratory studies are focused on a series of identical bioreactors which are being used to develop an understanding of the kinetics, growth characteristics, and viability of the microbial population in the reactors through variation of key parameters. These studies have provided insight into system control issues, development of advanced reactor design concepts, and establishment of key parameter values for the mathematical modeling effort. The full-scale experimental studies are being used to develop a complete water reclamation system founded on a biologically-based primary water processor.