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Computer models are currently being developed by NASA and major aerospace companies to characterize regenerative life support waste water reclamation bioreactors. Detailed models increase understanding of complex processes within the bioreactors and predict performance capabilities over a wide range of operating parameters. Bench-top scale bioreactors are contributing to the development and validation of these models. The purpose of the detailed bioreactor model is to simulate the complex water purification processes as accurately as possible by minimizing the use of simplifying assumptions and empirical relationships. Fundamental equations of mass transport and microbial kinetics were implemented in a finite-difference model structure to maximize accuracy and adaptability to various bioreactor configurations. The model development is based upon concepts and data from the available literature and data from the bench top bioreactor investigations.