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The chemistry involved in the selective catalytic reduction of oxides of nitrogen (NOx) to nitrogen is outlined and the requirements of a practical NOx reduction catalyst are summarized. The effects of temperature, gas composition, NOx concentration, and sulfur dioxide on the activity of some potential NOx catalysts have been studied. Steady-state engine dynamometer endurance runs with ruthenium and non-ruthenium catalysts are described, and some vehicle durability data with particulate and monolithic base metal containing NOx catalysts are also presented.