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The International Space Station Alpha (ISSA) Node 1 ducting and ventilation system has been reconfigured from the Space Station Freedom (SSF) configuration to meet new interface requirements and work with a new parasitic air cooling scheme with an adjacent module. The ducting system has been redesigned for sound attenuation and to accommodate different air interfaces at some ports for different stages of Station assembly. This paper describes the Node 1 ducting system in detail, compares SSF cabin air velocity data with ISSA analytical predictions, and shows that overall the Node ventilation system will meet ISSA requirements. Centerline and average cabin velocities are examined for different regions of the Node and the different air supply diffusers used are described.