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The use of composting technology is attractive to NASA’s Bioregenerative Life Support System (BLSS) research because it offers a potential reduction in system costs when compared to other waste recycling approaches. Water-soluble leachates from 28-day composted fresh or oven-dried inedible wheat biomass were amended with reagent-grade nutrients to be inorganically equivalent to ½-strength Hoagland’s (control) replenishment solution. A portion of the fresh and oven-dried compost leachate was filtered to remove large organic particles and a majority of the microflora, and wheat plants were grown hydroponically on these amended leachates. For both the fresh and oven-dried compost leachate treatments, filtering the leachate had no effect on plant response. No significant difference was observed between the fresh compost leachate treatments and the control.