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Independent temperature and humidity control may be required for a variety of reasons. One application under study at the NASA Johnson Space Center is the environmental control of completely sealed plant growth chambers. The chambers are used to optimize plant growth and to develop engineering prototypes of future plant growth chamber modules for long duration space travel. One chamber at the Johnson Space Center which is part of the Early Human Test Initiative was rebuilt and upgraded during 1994. Requirements called for a thermal control system which could supply the plants with a wide range of air temperatures and independently control humidity. A math model was developed using G189 thermal/environmental modeling software to simulate the internal environment of the plant growth chamber. The model was used in the design of the chamber thermal control system.