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In this paper, an advanced trace gas monitoring system for manned space cabins is presented. The principle of functioning of the measurement system is based on the detection of gas-specific absorption features in the Infrared area of the spectrum. The core element in the monitoring system is a Fourier-Transform Infrared (FTIR) Spectrometer. When calibration is carried out applying sophisticated, novel analysis methods, the system can simultaneously detect and quantify all the interesting gases in manned space cabins. In a previous Trace Gas Monitoring multi-phase program (TGM 2) [1],[2], the FTIR technology has demonstrated its ability to handle multi-component, quasi on-line gas measurements, including identification and quantification of 23 important trace gases in a mixture. In the ongoing phase 3 (TGM 3), initiated end of 1997 [3], a fully operational FTIR technology demonstration model is tested being able to detect simultaneously 30 different trace gases in a mixture.