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Euro IV-V and US 2007-2010 emission control regulations, combined with changing engine-out emission characteristics of advanced diesel combustion systems result in different performance and durability requirements for diesel oxidation catalysts depending upon specific platforms and regulation levels. A rational catalyst design approach has been utilized to develop a series of catalysts with performance, durability, and PGM utilization characteristics to meet different system requirements. Promoted-Pt catalysts with 40 °C lower CO light-off temperatures and improved thermal durability compared to Pt-only formulations have been developed for use in applications with low exhaust temperatures. The promoted-Pt catalysts also provide tunable NO oxidation activity, which is important for NO/NO2 control (SCR) and areas where excessive NO2 emissions are of concern.