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The complex nature of the challenge as humans embark on exploration missions beyond Earth orbit will require that, in the early stages, simulation facilities be established at least on Earth. Suitable facilities in Low Earth Orbit and on the Moon surface would provide complementary information of critical importance for the overall design of a human mission to Mars. A full range of simulation campaigns is required, in fact, to reach a better understanding of the complexities involved in exploration missions that will bring humans back to the Moon and then outward to Mars. The corresponding simulation means may range from small scale environmental simulation chambers and/or computer models that will aid in the development of new materials, to full scale mock-ups of spacecraft and planetary habitats and/or orbiting infrastructures.