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Water recovery from wastewater is essential for the success of long term missions. Honeywell Aerospace and the team comprising Thermodistillation Co. (Kiev, Ukraine) and NASA JSC Crew and Thermal Systems Division are developing an advanced wastewater processing subsystem that is based on centrifugal vacuum distillation that will be tested at the NASA JSC water lab. The wastewater processing cascade distillation subsystem (CDS) utilizes a multi-stage thermodynamic process to efficiently produce purified water, and its rotary centrifugal design provides gas/liquid phase separation and liquid transport (pumping) under microgravity conditions. The objective of the program is to demonstrate potable water recovery from various wastewater streams that is suitable to meet the requirements of present (ISS) and future (Lunar-Mars) human space missions. This paper presents the subsystem design and the cascade distiller operational evaluation.