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Introduction: There are contradictory opinions regarding the contribution of local hand thermal insulation to support local and total comfort during extravehicular activity (EVA). Instead of a local correction by means of thermal insulation on the periphery of the body to prevent heat dissipation, it may be optimal to prevent heat dissipation from the body core. To examine such a concept, the effects of different insulation levels on the left and right hands on the heat flux and temperature mosaic on the hands was measured. These variables were assessed in relation to the level of heat deficit forming in the core organs and tissues. Methods: Six subjects (4 males, 2 females) were donned in a liquid cooling/warming garment (LCWG) that totally covered the body surface except for the face. Participants wore the Phase VI space gloves including the entire micrometeoroid garment (TMG) on the left hand, and the glove without the TMG on the right hand.