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The Advanced Animal Habitat (AAH) represents the next generation of Space Station based animal research facilities. Care has been taken to protect the ISS crew from exposure to the hazardous biological materials contained within the AAH. These materials include rat feces, urine, dander, and odor. The approach to containing biological materials relies on collecting the solid and liquid waste, providing physical barriers between the waste and the crew environment, maintaining negative pressure within the specimen environment with respect to the crew environment, and providing odor filtration of air exchanged between the specimen and crew environments. These protections will be in place during all modes of AAH operation.