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The Space Shuttle Orbiter Pressure Control System uses an electrochemical oxygen partial pressure (PPO2) sensor with an amplifier to provide continuous monitoring and control signals to maintain oxygen concentrations in a two gas cabin atmosphere. Due to manufacturing complications, the need for a replacement sensor was identified. A program was initiated by NASA/Johnson Space Center (JSC) to develop a longer life sensor which would satisfy all of the existing interface requirements without modifications to the remainder of the system. As a result, a low cost, high accuracy, replacement sensor has been developed and is planned for use on future Shuttle Orbiter missions. In addition to the oxygen sensor, a redesign of the amplifier assembly has been proposed which will provide higher accuracy and greater output signal gain adjustment. The increase in gain adjustment will provide increased sensor utilization time.